Covid-19 vaccine AstraZeneca

Covid-19 vaccine AstraZeneca

The University of Oxford partnered with the British-Swedish company AstraZeneca to develop and test a coronavirus vaccine known as ChAdOx1 nCoV-19 or AZD1222.

''Covid-19 Vaccine AstraZeneca is a monovalent vaccine composed of a single recombinant, replication-deficient chimpanzee adenovirus (ChAdOx1) vector encoding the S glycoprotein of SARS-CoV-2. The SARS-CoV-2 S immunogen in the vaccine is expressed in the trimeric pre-fusion conformation; the coding sequence has not been modified in order to stabilise the expressed S-protein in the pre-fusion conformation. Following administration, the S glycoprotein of SARS-CoV-2 is expressed locally stimulating neutralising antibody and cellular immune responses, which may contribute to protection to covid-19.''

News

 * 22 Mar 2021, Bloomberg.com, Astra vaccine 79% effective in US, shows no safety issues
 * 19 Mar 2021, Politico.eu, French authority says AstraZeneca vaccine should only go to those over 55, The recommendation comes just a day after the government announced that vaccination with the jab would resume.
 * 18 Mar 2021, Economist.com, Another shot in the foot. How Europe’s vaccine caution can cost lives, Avoid a small risk; incur a bigger one
 * 18 Mar 2021, Politico.eu, Revenge of the precautionary principle, Europe’s aversion to risk may end up costing lives, as countries rush to suspend AstraZeneca vaccine.
 * 18 Mar 2021, Politico.eu, EU drugs regulator: Oxford/AstraZeneca vaccine is safe, Countries began reversing suspensions following the green light from the European Medicines Agency.
 * 18 Mar 2021, Politico.eu, Indian producer: Delhi behind UK coronavirus vaccine shortfall, Only 5 million doses, out of 10 million ordered from India-based SII, will arrive in March in the U.K.
 * 18 Mar 2021, Politico.eu, EU drugs regulator: Oxford/AstraZeneca vaccine is safe, The decision comes after 20 EU countries either suspended, entirely or partially, their vaccination program with Oxford/AstraZeneca’s jab.
 * 16 Mar 2021, Politico.eu, Politics threaten to cloud EU countries’ pause of Oxford/AstraZeneca vaccine, It’s the second time numerous EU countries have diverged with the European Medicines Agency over the Oxford/AstraZeneca vaccine.
 * 15 Mar 2021, Politico.eu, More countries pause Oxford/AstraZeneca vaccine against EU regulator’s advice, The European Medicines Agency maintains the benefits of vaccination outweigh the risks.
 * 15 Mar 2021, Economist.com, EU countries pause AstraZeneca’s covid-19 jab over safety fears, An abundance of caution could well backfire
 * 14 Mar 2021, AstraZeneca, Update on the safety of covid-19 Vaccine AstraZeneca
 * 11 Mar 2021, Politico.eu, EU countries halt Oxford/AstraZeneca vaccine rollout over blood clots, Medicines agencies are seeking to quell fears, noting no causal link has been made. [...] "the enormous difficulty of distinguishing a causal effect from a coincidence." [...] In the U.K., more than 11 million doses of the Oxford/AstraZeneca vaccine have been administered — more than double the number across Europe. The weekly adverse reaction report, updated Thursday, shows there have been three deaths and 45 non-fatal blood clot-related events in the aftermath of getting the Oxford/AstraZeneca vaccine, and one death and 48 non-fatal blood-clot related events after the BioNTech/Pfizer jab.
 * 11 Mar 2021, Politico.eu, Denmark suspends rollout of Oxford/AstraZeneca vaccine following cases of severe blood clots, The announcement follows initial reports in Austria of cases of blood clots after vaccination, which led to the suspension of a specific batch in the country.
 * 04 Mar 2021, Politoco.eu, Italy blocks shipment of Oxford/AstraZeneca vaccine headed to Australia, The EU’s export scheme requires companies to get explicit authorization from national authorities before exporting vaccines.
 * 03 Mar 2021, Politico.eu, Breton: No AstraZeneca jabs exported from the Netherlands after EU export controls, The Dutch site Halix has been a source confusion in the puzzle over why AstraZeneca fell more than 60 million doses short of its pledged EU delivery in the first quarter. The EU has largely blamed AstraZeneca, saying it sent those vaccines to the U.K.
 * 02 Mar 2021, Politico.eu, UK to import vaccine doses from India amid global jabs race, The U.K. will receive its first tranche of 10 million Indian-made Oxford/AstraZeneca doses next week, according to U.K. officials, allowing Britain to speed ahead in vaccinations while less wealthy countries wait.
 * 02 Mar 2021, FDANews.com, EU assessing Serum Institute of India’s AstraZeneca vaccine production
 * 26 Feb 2021, Fortune.com, The FDA’s foot-dragging on the AstraZeneca vaccine is indefensible
 * 22 Feb 2021, Politico.eu, How the UK gained an edge with AstraZeneca’s vaccine commitments, A comparison of the UK and EU contracts shows that London’s deal has extra teeth.
 * 12 Feb 2021, Politico.eu, After failing to deliver, AstraZeneca rethinks EU coronavirus vaccine supply chain, The British-Swedish drugmaker is signing new manufacturing deals.
 * 10 Feb 2021, Politico.eu, Von der Leyen: ‘Mistakes were made’ on vaccine export ban but ‘we got it right’: "If the United Kingdom is not willing to deliver doses to Europe, then why should we deliver doses to the United Kingdom?" Weber asked.
 * 10 Feb 2021, Politico.eu, Belgian plant blamed for AstraZeneca vaccine shortage says it met all deliveries
 * 10 Feb 2021, Reuters.com, Belgian plant Novasep says it complies with AstraZeneca contract amid vaccine supply cuts: The factory, which U.S. firm Thermo Fisher Scientific acquired from Novasep in January, has been identified as the cause of the cuts by AstraZeneca in internal meetings, several EU officials have said.
 * 03 Feb 2021, Politico.eu, Switzerland won’t authorize Oxford/AstraZeneca vaccine, citing lack of data: Swiss regulators first want to see data from large-scale human trials.
 * 02 Feb 2021, Politico.eu, France, Sweden, Poland: Oxford/AstraZeneca vaccine not for elderly: The French health authority cited insufficient data on the elderly to make a conclusion.
 * 29 Jan 2021, Politico.eu, EU approves Oxford/AstraZeneca vaccine but fails to erase doubts: German scientists stood by their call that there isn’t enough data to know whether use the vaccine in people over 65.
 * 29 Jan 2021, Politico.eu, EU regulator OKs Oxford/AstraZeneca coronavirus vaccine for all adults, The viral vector vaccine was long seen as the front-runner but was delayed after clinical trial issues in the fall.
 * 29 Jan 2021, Politico.eu, Redacted contract fails to clear up EU-AstraZeneca vaccine row, It’s still not clear how many doses the firm committed to provide in the first quarter.
 * 28 Jan 2021, Politico.eu, AstraZeneca’s ‘best efforts’ defense isn’t bulletproof, The phrase is at the heart of a battle over the EU’s delayed vaccine delivery.
 * 27 Jan 2021, Politico.eu, EU commissioner: AstraZeneca logic might work at the butcher’s, but not in vaccine contracts, ‘We reject the logic of first come, first served,’ says Health Commissioner Stella Kyriakides.
 * 30 Dec 2020, AstraZeneca.com, AstraZeneca’s covid-19 vaccine authorised for emergency supply in the UK

Studies

 * 3 Mar 2021, (fr) MesVaccins.net, Le vaccin "COVID-19 Vaccine AstraZeneca" peut être utilisé à tout âge chez les adultes, L'efficacité du vaccin d'AstraZeneca atteint 82 % après deux doses administrées à 12 semaines d'intervalle L'efficacité vaccinale contre les formes les plus graves de la covid 19 est proche de 100 % après 22 jours  La dose réduite qui avait paru procurer une meilleure efficacité dans un premier essai ne sera pas recommandée  Une protection contre la transmission du virus peut être attendue